激酶LMTK3在前列腺癌组织中的表达及临床意义

目的:探讨狐猴酪氨酸激酶3(LMTK3)在前列腺癌组织中的表达及临床意义。方法:应用免疫组织化学方法检测55例前列腺癌及25例前列腺增生组织中LMTK3和雌激素受体α(ERα)蛋白的表达水平。应用χ2检验和Fisher确切概率法评估LMTK3和ERα的表达水平与临床病理资料间的关系。应用Pearson和Spearman相关性分析验证LMTK3和ERα之间的相关性。结果:55例前列腺癌组织中LMTK3和ERα蛋白表达的阳性率分别为36. 36%和32. 73%,而25例前列腺增生组织中LMTK3和ERα蛋白表达的阳性率分别为64. 00%和56. 00%,两组结果比较差异均具有统计学意义(P<0. 05); ERα蛋白的表达随着TPSA含量的升高而降低,LMTK3和ERα蛋白在前列腺癌中的表达与Gleason分级均呈负相关性(P<0. 05),而LMTK3与TPSA含量无明显相关性,二者与年龄、TNM分期和有无淋巴结转移亦无明显相关性(P>0. 05); Pearson和Spearman相关性分析显示LMTK3和ERα之间存在正相关关系(r=0. 296,P<0. 05)。结论:LMTK3在前列腺癌组织中低表达,与Gleason分级呈负相关性,与ERα表达存在正相关关系。

Expression and clinical significance of LMTK3 in prostate cancer tissues

Objective:To investigate the expression and clinical significance of LMTK3 in patients with prostate carcer.Methods:Immunohistochemistry was used to detect the expression of LMTK3 and ERαin 55 cases of prostate cancer tissues and 25 cases of benign prostatic hyperplasia tissues.The relationship between the expression of LMTK3 and ERαand clinicopathological parameters was evaluated by square test and Fisher exact test.The association between LMTK3 and ERαexpression was analyzed with Pearson and Spearman rank correlation.Results:The results of immunohistochemistry demonstrated that the LMTK3 and ERαprotein positive expression rate in 55 cases of prostate cancer tissues was 36.36%and 32.73%,whereas was 64.00%and 56.00%in the benign prostatic hyperplasia,respectively,showed a significant difference of comparison within this result(P<0.05).The expression of LMTK3 in prostate cancer tissues was inversely related with the level of Gleason grade(P<0.05),but no relation with the levels of age,TPSA,TNM stage and lymph node metastasis(P >0.05).Moreover,the expression of ERαin prostate cancer tissues was oppositely related with the levels of gleason grade and TPSA(P<0.05),but no relation with the levels of age,TNM stage and lymph node metastasis(P >0.05).Pearson and Spearman rank correlation analysis revealed,to some extent,there was positively correlated with the two proteins(r=0.296,P<0.05).Conclusion:The expression of LMTK3 in prostate cancer tissues was decreased compared with benign prostatic hyperplasia tissues and negatively related with the level of gleason grade.In some degree,there is a positively correlation between the LMTK3 and ERαproteins.