酒精所致震颤谵妄患者血液相关指标的对照研究

目的:对酒依赖患者进行血液相关指标的观察与分析,探讨慢性酒精中毒患者发生震颤谵妄(delirium tremens,DT)的高危因素. 方法:对近4年142例首次住院的男性酒依赖住院患者按照是否出现DT分组进行血液相关指标比较. 结果:出现震颤谵妄(DT)的17例酒依赖患者与非震颤谵妄组相比,在谷草转氨酶(183.53±174.55) U/L;(95.83±118.38) U/L]、谷氨酸转氨酶(647.26±618.27)U/L; (250.48±313.91) U/L]、及肌酸激酶(738.85±1023.72)U/L;(330.59±433.42) U/L]及钙(2.34±0.91) mmol/l;(2.22±0.14) mmol/l]显著升高；而血红蛋白(126.00±17.77) g/l;(135.38±17.85) g/l]、红细胞(3.55±0.64)×1012/L; (3.93±0.60)×1012/L]、血小板(86.41±31.56)×109/L;(173.78±79.44)×109/L]、钾(3.45 ±0.75)mmol/l;(3.88±0.55) mmol/l]及氯(100.94±5.02) mmol/l；(104.46±6.64) mmol/l]则显著降低,差异均有统计学意义(P＜0.05或P＜0.01).Logistic回归分析显示,戒酒患者发生DT的危险因素有:血小板减少和血钾降低. 结论:酒依赖患者血液相关指标对DT预测具有一定参考意义.

The measurement of blood related indexes in the patients with delirium tremens due to alcohol dependence

Objective:To investigate the blood related indexes in the patients with delirium tremens due to alcohol dependence and explore the high risk factors for delirium tremens.Method:142 male inpatients with alcohol dependence were divided into two groups (delirium tremens and non delirium tremens) in terms of delirium tremens occurrence.The blood related indexes were measured and compared between the two groups.Results:Compared non delirium tremens group,delirium tremens group showed higher levels on AST (aspartate aminotransferase) (183.53±174.55)U/L vs.(95.83±118.38)U/L],GGT (glutamate transaminase) (647.26±618.27)U/L vs.(250.48±313.91)U/L],CK(creatine kinase)(738.85±1023.72)U/L vs.(330.59±433.42)U/L] and Ca (2.34±0.91) mmol/l vs.(2.22±0.14)mmol/l],and lower levels in HGB (hemoglobin) (126.00±17.77)g/l vs.(135.38±17.85)g/l],RBC(red blood cell)(3.55±0.64)×1012/L vs.(3.93±0.60)×1012/L],PLT (platelet count)(86.41±31.56)×109/L vs.(173.78±79.44)×109/L],K(3.45±0.75)mmol/L vs.(3.88±0.55)mmol/L] and Cl (100.94±5.02)mmol/L vs (104.46±6.64)mmol/L].The above index differences between the two groups were statistically significant (P<0.05 or P<0.01).Logistic regression analysis indicated that thrombocytopenia and low serum potassium were risk factors fro delirium tremens.Conclusion:The blood related indexes in patients with alcohol dependence to some degree can predict delirium tremens onset.