Different behavioral deficits are induced by anoxia/hypoxia in neonatal and senescent rats: blockade by MK-801 |
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Authors: | Z Speiser J Uziel R Defrin-Assa S Gitter G Urca |
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Affiliation: | Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Israel. |
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Abstract: | Rats exposed on their first postnatal day to 100% nitrogen for 25 min developed hyperactivity and lower performance in passive avoidance task during development. Administration of MK-801 (0.5 mg/kg i.p.) 1 h before anoxia or (0.25 and 0.5 mg/kg) 1 h after completely reversed this behavioral impairment. Senescent rats (24-26 months) exposed to hypoxia (92% N2 + 8% O2) for 5 h failed in their performance in C.A.R., 30 days later. Pretreatment with MK-801 (1 mg/kg i.p.) completely reversed this impairment. These data suggest that activation of endogenous NMDA receptors produces different behavioral consequences in neonatal and senescent rats and that MK-801 administration close to exposure of animals to anoxia or hypoxia can prevent such damage, thus preventing behavioral impairments in postnatal as well as in senescent rats. |
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