多发性硬化的临床观察

目的　探讨多发性硬化 (MS)的临床特点。方法　综合分析 4 1例MS患者的一般临床资料、病变部位、重要辅助检查及治疗转归。结果　MS多见于青年女性 ,病程多出现缓解与复发 ,上呼吸道感染、劳累可为其诱因 ,磁共振成像 (MRI)、电生理、免疫学有助诊断 ,视神经、脊髓受累多见 ,脑脊液显示免疫活性增高 ,糖皮质激素 +免疫抑制剂治疗有效。结论　根据临床特点、结合MRI、神经电生理及脑脊液免疫学能明显提高临床确诊率。

Clinical observation of multiple sclerosis

Objective To study the clinical features of multiple sclerosis (MS).Methods General clinical manifestations,lesion locations,results of cardinal ancillary examinations,treatment and prognosis of 41 MS patients were comprehensively analyzed.Results MS mainly affected young and middleaged women.Alleviation and recurrence of the disease happened alternately during the course.Upper respiratory tract infection and tiredness were the main inducements.MRI,electrophysiology and immunology were helpful to diagnosis.Optic nerves and spinal cord were often involved.The immunocompetence of cerebrospinal fluid (CSF) was increased.Glucocorticoid plus immunosuppressant therapy was effective.Conclusion In addition to clinical features,MRI,neuroelectrophysiology and CSF immunology altogether aid greatly clinical definite diagnosis.