Myocardial metabolism in a patient with Hashimoto's thyroiditis and hypothyroidism: Case report,with metabolic studies |
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| Affiliation: | 1. Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista Júlio de Mesquita Filho, Jaboticabal, São Paulo, Brazil;2. Faculdade de Ciências Farmacêuticas, Araraquara, São Paulo, Brazil;3. Centro Universitário Central Paulista, São Carlos, São Paulo, Brazil;4. Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho, Rio Claro, São Paulo, Brazil;5. Embrapa Pecuária Sudeste, São Carlos, São Paulo, Brazil;1. Tomsk State University, 36, Lenin Ave., Tomsk, 634050, Russia;2. Tomsk Polytechnic University, 30, Lenin Ave., Tomsk, 634050, Russia;1. Department of Clinical and Experimental Medicine, University of Messina, Viale Gazzi, 98125 Messina, Italy;2. Master Program on Childhood, Adolescent and Women’s Endocrine Health, University of Messina, Viale Gazzi, 98125 Messina, Italy;3. Interdepartmental Program of Molecular & Clinical Endocrinology and Women’s Endocrine Health, University Hospital, A.O.U. Policlinico G. Martino, Viale Gazzi, 98125 Messina, Italy;1. Unidad de Gestión de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla, Spain;2. Unidad de Gestión Clínica intercentros de Anatomía Patológica, Hospital Universitario Virgen del Rocío, Sevilla, Spain;1. Unidad de Gestión de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla, España;2. Unidad de Gestión Clínica Intercentros de Anatomía Patológica, Hospital Universitario Virgen del Rocío, Sevilla, España |
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| Abstract: | A case of Hashimoto's thyroiditis with clinical and pathologic evidence of hypothyroidism is presented. Cardiac output, coronary blood flow and myocardial oxygen consumption were within the normal range. Pyruvate and lactate were extracted by the heart during the basal state and released by the heart on exercise. A marked increase in myocardial glucose: oxygen extraction ratio was found and the differences in oxidation reduction potential between arterial and coronary vein blood were positive at rest and exercise. The results suggest glycolysis in the cardiac muscle of this individual in the presence of normal myocardial oxygen usage. |
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