Clinical observations on the antihypertensive response to mebutamate (Capla) in geriatric patients |
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| Affiliation: | 1. Division of Cardiology, Department of Medicine, University of Oregon Medical School, Portland, Ore. USA;2. Division of Neurology, Department of Medicine, University of Oregon Medical School, Portland, Ore. USA;1. Laboratory of Pharmacology, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan;2. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan;3. Department of Applied Pharmacology, Graduate School of Medical and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan;1. Department of Cardiovascular Medicine, Endocrinology and Metabolism, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan;2. Division of Pharmacology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan;3. Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science, 86 Nishi-cho, Yonago 683-8503, Japan;1. Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran;2. Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran;3. Department of Physiology and Cell Biology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA;1. Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran;2. Department of Cardiovascular Surgery, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, Iran;3. Department of Physiology and Cell Biology, College of Medicine, The Ohio State University, Columbus, OH, United States;4. Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, United States |
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| Abstract: | Nineteen geriatric patients with sustained, mild to moderate hypertension in addition to cerebrovascular disease were studied for 4 months by means of a double-blind crossover technique in which mebutamate was compared to an inert placebo.No significant antihypertensive effect was observed in the 19 geriatric patients treated with mebutamate (Capla). Over 40 per cent of the patients complained of drowsiness while receiving the drug.There was no evidence of renal or hepatic impairment during the period of observation. |
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