慢性阻塞性肺疾病长期家庭氧疗的临床观察

目的观察长期家庭氧疗（LTDOT）对慢性阻塞性肺疾病（COPD）患者的治疗效果。方法将COPD患者随机分为LTDOT组和对照组，每组各26例，常规治疗相同，LTDOT组进行LTDOT，对照组在家无氧疗。两组于缓解期治疗前及治疗后2年测定肺功能、血气分析、进行生活质量评估等。结果治疗后2年LTDOT组第1秒用力呼气容积（FEV1）为（1．42±0．42）L，动脉血氧分压（PaO2）为（80．0±2．6）mmHg（1mmHg=0．133kPa），与对照组的（0．72±0．38）L、（55．0±2．2）mmHg比较差异有统计学意义（P〈0．01）；最大肺活量、动脉血二氧化碳分压两组比较差异无统计学意义（P〉0．05）；生活质量评分LTDOT组优于对照组；LTDOT组急诊次数为（2．3±1．2）次，住院时间为（16．0±2．4）d，与对照组的（5．2±1．3）次、（36．0±2．2）d比较差异有统计学意义（P〈0．01）。结论COPD缓解期患者行LTDOT能增加FEV1、PaO2，提高生活质量，减少急诊次数和住院时间。

Clinical observation for long-term domiciliary oxygen therapy on chronic obstructive pulmonary disease

Objective To observe the clinical effect of long-terra domiciliary oxygen therapy （LTDOT） on chronic obstructive pulmonary disease （COPD）. Methods COPD patients were randomly divided into LTDOT group and control group, LTDOT group received LTDOT on basis of conventional therapy, and control group only received conventional therapy. The lung function, blood gas analysis was detected and quality of life in paracmasis before and after treatment was evaluted. Results After two years, FEV1[ （ 1.42 ± 0.42） L], PaO2[ （80.0 ± 2.6） nun Hg, 1 mm Hg = 0.133 kPa] in LTDOT group were obviously higher than those in control group [ （0.72 ± 0.38 ） L,（55.0 ± 2.2） mm Hg], there were significant differences between two gxoups（P 〈 0.01 ）. FVC, PaCO2 in two groups were no significant difference （P〉 0.05）. Quality of life in LTDOT group was better than that in control group, average emergency frequency[ （2.3 ± 1.2） times] and hospital day [（16.0 ±2.4） d] in LTDOT group were obviously decreased than those in control group [ （5.2 ± 1.3） times, （36.0 ± 2.2） d ] （P 〈 0.01 ）. Conclusion For the patients with COPD paraemasis, LTDOT can increase FEV1, PaO2, elevate quality of life and decrease average emergency frequency and hospital day.