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| 核苷酸适体在靶向给药系统中的应用进展 | |
| 引用本文： | 熊叶,台宗光,李强. 核苷酸适体在靶向给药系统中的应用进展[J]. 药学实践杂志, 2015, 33(6): 490-493,532 |
| 作者姓名： | 熊叶 台宗光 李强 |
| 作者单位： | 第二军医大学附属长海医院, 上海 200433,第二军医大学附属长海医院, 上海 200433;解放军92330部队医院, 山东 青岛 266102,第二军医大学附属长海医院, 上海 200433 |
| 基金项目： | 国家自然科学基金项目(No.81170060) |
| 摘 要： | 适体,即体外合成筛选得到的能特异性地与靶分子结合的一段寡核苷酸序列。由于其独特的性质,在靶向给药系统中有着广阔的应用前景,目前已成为靶向给药研究领域的热点。综述了适体在靶向给药系统中的优势及其应用进展,并对其应用前景和面临的问题进行分析。 |
| 关 键 词： | 核苷酸适体 靶向给药 应用进展 |
| 收稿时间： | 2013-11-04 |
| 修稿时间： | 2014-12-24 |
Application progress of nucleic acid aptamers in targeted drug delivery system |
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| XIONG Ye,TAI ZongGuang and Li Qiang. Application progress of nucleic acid aptamers in targeted drug delivery system[J]. The Journal of Pharmaceutical Practice, 2015, 33(6): 490-493,532 | |
| Authors: | XIONG Ye TAI ZongGuang Li Qiang |
| Affiliation: | Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China,Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Hospital of CPLA No.92330 Troop, Qingdao 266102, China and Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China |
| Abstract: | Aptamers are single stranded oligonucleotides that have high affinity and specificity towards a wide range of target molecules. Owing to the indispensable advantages, aptamers have wildly prospects and have become a research hotspot in targeted drug delivery system (TDDS). In this article, application advantage and progress of aptamers in TDDS were briefly reviewed, the problems and prospects were also discussed. |
| Keywords: | nucleic acid aptamers targeted drug delivery application progress |
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