| 肝移植术后服用他克莫司致神经毒性反应的观察 |
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| 引用本文： | 魏淑贞,张德奎,姜山,藏运金. 肝移植术后服用他克莫司致神经毒性反应的观察[J]. 中国现代医学杂志, 2004, 14(6): 90-91 |
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| 作者姓名： | 魏淑贞 张德奎 姜山 藏运金 |
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| 作者单位： | 1. 山东省青岛市第八人民医院药剂科,山东,青岛,266100
2. 山东省千佛山医院,山东,济南,250014 |
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| 摘 要： | 目的探讨肝移植术后如何安全有效地服用他克莫司(FK506).方法对16例肝移植病人术后他克莫司用量、血药浓度及他克莫司对神经毒性损害进行对比观察.结果不同时间段,他克莫司用药剂量大小、血药浓度高低对神经损害副反应差异有极显著性.结论他克莫司是肝移植术后安全有效的强免疫抑制剂,其神经毒副反应与他克莫司用药剂量大小、血药浓度高低及合并应用潜在性的神经毒性药物呈正相关关系.
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| 关 键 词： | 肝移植 他克莫司 神经毒性 |
| 文章编号： | 1005-8982(2004)06-0090-02 |
Study on neurotoxicity of FK506 after liver transplantation |
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| WEI Shu-zhen ,ZHANG De-kui ,JIANG Shan and CANG Yu n-jin. Study on neurotoxicity of FK506 after liver transplantation[J]. China Journal of Modern Medicine, 2004, 14(6): 90-91 |
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| Authors: | WEI Shu-zhen ZHANG De-kui JIANG Shan CANG Yu n-jin |
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| Affiliation: | WEI Shu-zhen 1,ZHANG De-kui 1,JIANG Shan 1 and CANG Yu n-jin 2 |
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| Abstract: | Objective: To study the application of FK506 after liver transplantation. Methods :16 cases of liver transplantation were applied FK506. The blood conc entration of FK506 and its neurotoxicity were detected. Results: The neurotoxic effects was obviously different with different dosage of FK50 6 according to different period post-operation,as well as different blood concen trations of FK506. Conclusions: FK506 was a potential immunosu ppressive agent for liver transplantation. And the neurotoxicity of FK506 we re related with its dosage,blood-concentration,liver function and concurre nt use of other neurotoxic agents,such as Ganciclovir and Aciclovir. |
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| Keywords: | liver transplantation FK506 neurotoxicity |
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