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Prognostic significance of microRNA-203 in cholangiocarcinoma
Authors:Jingjing Li  Beibei Gao  Zufa Huang  Tong Duan  Daiqiang Li  Sheng Zhang  Yujun Zhao  Lian Liu  Qiang Wang  Zhizhao Chen  Ke Cheng
Affiliation:1.Department of Pathology, Xiangya Basic Medical College, Central South University, Changsha 410013, China;2.Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha 410013, China;3.Transplantation Center, The Third Xiangya Hospital of Central South University, Changsha 410013, China;4.Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha 410013, China
Abstract:
MircroRNA functions as a tumor suppressor or a promoter in cholangiocarcinoma (CCA). Researchers have found that miR-203 functioned as tumor suppressor in many types of cancer. However, the role of miR-203 that plays in CCA remains to be clarified. We aimed to detect the expression level and the prognostic significance of miR-203 in CCA tissues. qRT-RCR was performed to examine the miR-203 expression levels in CCA tissue specimens and corresponding normal tissues. Our findings suggest that miR-203 expression was an independent poor prognostic factor for CCA patient overall survival. Therefore, miR-203 may serve as a valuable prognostic marker and promising treatment target for CCA.
Keywords:mircroRNA   miR-203   cholangiocarcinoma   prognosis
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