Investigation of memory B cell responses to hepatitis B surface antigen in health care workers considered as non-responders to vaccination |
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| Authors: | J.C. Valats,E. Tuaillon,N. Funakoshi,D. Hoa,M.C. Brabet,K. Bolloré ,J. Ducos,J.P. Vendrell,P. Blanc |
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| Affiliation: | 1. Service d’Hépato-gastroentérologie B, Hôpital Saint Eloi, CHU Montpellier, France;2. Laboratoire de virologie, Hôpital Lapeyronie, CHU Montpellier, France;3. EA 4205, Institut de recherche en Biothérapie, Hôpital Saint Eloi, CHU Montpellier, France;4. IMAIOS SAS, Département CRO, Montpellier, France;5. Médecine du travail, Hôpital Saint Eloi, CHU Montpellier, France |
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| Abstract: | ![]()
Up to 20% of health care workers are considered as non-responders to hepatitis B vaccination (anti-HBs < 10 mUI/ml in serum). We have explored memory B cells differentiated in vitro into anti-HBs antibody-secreting cells (anti-HBs-SCs) by ELISPOT assay. Anti-HBs-SCs were detected in vaccinated responders (n = 11) and non-responders (n = 10) but IgG anti-HBs-SCs were significantly lower in the non-responder group (p < 0.001). Low amounts of HBs antibodies were also quantified by ELISA in non-responders’ sera. These results indicate that a suboptimal B cell response exists in non-responders to HBV vaccination. This B cell response may mediate a protection against clinically significant breakthrough hepatitis B infection. |
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| Keywords: | Hepatitis B Vaccination Memory B cell |
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