HSP65 DNA as therapeutic strategy to treat experimental paracoccidioidomycosis |
| |
| Authors: | Alice M. Ribeiro,Anamelia L. Bocca,André C. Amaral,Ana Camila C.O. Souza,Lú cia H. Faccioli,Arlete A.M. Coelho-Castelo,Florê ncio Figueiredo,Cé lio L. Silva,Maria Sueli S. Felipe |
| |
| Affiliation: | 1. Laboratory of Pathology, Faculty of Medicine, University of Brasília, 70910-900 Brasilia, DF, Brazil;2. Biological Sciences Institute, University of Brasília, 70910-900 Brasilia, DF, Brazil;3. Genomic Science and Biotechnology, Catholic University of Brasilia, 70790-160 Brasília, DF, Brazil;4. Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903 Ribeirão Preto, SP, Brazil;5. Farmacore Biotecnology Ltd., 14049-900 Ribeirão Preto, SP, Brazil;6. Center for Tuberculosis Research, School of Medicine of Ribeirão Preto, Millennium Institute of Network-TB, University of São Paulo, 14049-900 Ribeirão Preto, SP, Brazil |
| |
| Abstract: | ![]()
The conventional treatment for paracoccidioidomycosis, the most prevalent mycosis in Latin America, involves long periods of therapy resulting in sequels and high frequency of relapses. The search for new alternatives of treatment is necessary. Previously, we have demonstrated that the hsp65 gene from Mycobacterium leprae shows prophylactic effects against murine paracoccidioidomycosis. Here, we tested the DNAhsp65 immunotherapy in BALB/c mice infected with Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis. We observed an increase of Th1 cytokines accompanied by a reduction in fungal burden and pulmonary injury. These results provide new prospects for immunotherapy of paracoccidioidomycosis and other mycoses. |
| |
| Keywords: | Immunotherapy DNAhsp65 Paracoccidioidomycosis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
