利培酮与氯氮平治疗精神分裂症患者生活质量对照研究的meta分析

目的 比较利培酮与氯氮平治疗精神分裂症患者疗效及对生活质量的影响。方法对包括988例 精神分裂症患者的8篇中国文献进行meta分析,其中利培酮组共计501例,氯氮平组487例。结果2组治疗后的 有显著疗效,但组间比较疗效差异无显著性意义。对采用WHOQOF-100量表中文版的5个调查资料综合分析后 发现:与氯氮平组相比,利培酮组患者的生活质量除生理领域略差外,其他领域及生活质量总体状况均优于氯氮平 组;失效安全数在17．25～311．23之间,可靠性好。对采用生活质量综合评定问卷(GQOLI)的4个调查资料综合分 析后发现:2组患者在物质生活维度无显著性差异,利培酮组在其他3个维度较氯氮平组好;除物质生活维度外,失 效安全数在74．39～94．39之间,可靠性较好。结论氯氮平和利培酮对精神分裂症均有较好的疗效,利培酮的比 氯氮平更有利于改善精神分裂症患者的社区康复功能,有利于患者重返社会。

Meta-analysis of comparative study on the quality of life of schizophrenia treated with risperidone and clozapine

Objective To compare the quality of life of two groups of schizophrenic patients who were treated with risperidone and clozapine respectively. Methods The compare effects differences in quality of life of 8 articles from China including 988 schizophrenic patients who were treated with risperidone(501) and clozapine(487) respectively were meta -analyzed. Results 5 samples investigated by WHOQOF-100 Chinese version were synthesized, showing that there are significant difference between treatment by risperidone and clozapine in the 6 domains and the overall of the quality of life of the patients. The effect of risperidone was better than that of clozapine on the quality of life of the patients in Psychological, Level of Independent,Social relations,Environment,Spiritdomains and the Overall of quality of life. However, the effect of clozapine was slightly better than that of risperidone on the quality of life of the patients in physical domain. The reliability was good. 4 samples investigated by GQOLI were synthesized, showing that risperidone group has better result in physical function, mental health, social function than clozapine group. Conclusions Resperidone is favorable for schizophrenic patients to return to society.