小茴香对5—氟脲嘧啶的促渗作用研究

目的：研究小茴香提取物及主要成分茴香醛、茴香脑等对5－氯脲嘧啶（5－Fu）的促渗作用。方法：采用体外透皮实验方法，用Valia-Chien水平扩散池为实验装置，测定模型药物5－氟脲嘧啶的累积渗透量及渗透系数、增渗倍数，确定其促渗效果的强弱。结果：完全了小茴香所含成分小茴香油、茴香脑、茴香醛等对5－氟脲嘧啶的促渗实验，上述药物对5－氟脲嘧啶均有一定的促渗作用，增渗倍数分别为7．14、4．17、9．54。结论：小茴香油、茴香脑、茴香醛等对5－氟脲嘧啶具有一定的促渗作用。

Study on Foeniculum Vulgare Mill as Penetration Enhancer for the Permeation of 5-Fluorouracil

Objective: To study the effect of volatile oils from Foeniculum Vulgare Mill, anisaldehyde, anethole and water extracts on the percutaneous penetration of 5 fluorouracil. Methods: With Valia Chien horizontal diffusion cell and HPLC method to observe the effect of volatile oils of Foeniculum Vulgare Mill, anisaldehyde, anethole on the percutaneous penetration of 5 fluorouracil. Results: The volatile oils of Foeniculum Vulgare Mill, anethole, anisaldehyde possessed the high promoting action on percutaneous absorption of 5 fluorouracil, and their enhancement ratio are 7.14, 4.17, 9.54, respectively. Conclusion: The volatile oils of Foeniculum Vulgare Mill, anethole, anisaldehyde enhance the skin permeation of 5 fluorouracil effectively.