慢性肝病141例与微量元素关系的研究

本文对141例慢性肝病(慢活肝30例,肝硬化111例)患者血、肝组织中微量元素锌、铜、铁的含量测定,并测定肝硬化患者血清铜兰蛋白含量及尿锌的排出量。结果血清中锌值均明显低于对照组(P<0.05),肝硬化较慢活肝更低,而铜与铜兰蛋白含量均明显高于对照组(P<0.01)。其中19例肝硬化患者作肝组织锌、铜测定,锌含量特别低,其均值比对照组低3倍(P<0.05),而铜含量则高于对照组1倍以上(P<0.05)。肝硬化患者24h尿锌排出量明显高于对照组(P<0.001)。通过对这些微量元素代谢变化的探讨,为慢性肝病治疗中纠正其代谢障碍提供了科学依据。

Chronic liver diseases and microelements

The levels of zinc, copper and iron in serum and in liver tissue were determined in 141 cases of chronic liver diseases including 104 post hepatic cirrhosis; 7 schistosomiasis and 30 chronic active hepatitis. The serum ceruloplasmin and urinary zinc excretion in cirrhosis group were also measured. The results showed that in study group the serum zinc was significantly lower than that of the control group, the cirrhosis group had lower value than that of the chronic active hepatitis. Serum copper and ceruloplasmin of study group were significantly higher than that of control group. Compared with the control group, the liver tissue zinc in cirrhotic group was significantly lower, whereas the copper higher, which indicated the excess storage of copper in the body. Serum iron was lower in study group, the lowest value was also in cirrhosis group. Our study indicated that the analysis of microele ments metabolism may be beneficial for the diagnosis and treatment of the chronic liver diseases.