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| 高亲和力IgE受体介导的信号传导及其相关的抑制性受体 | |
| 引用本文： | 孙仁山,陈晓红,冉新泽,程天民. 高亲和力IgE受体介导的信号传导及其相关的抑制性受体[J]. 中国药理学通报, 2005, 21(4): 385-389 |
| 作者姓名： | 孙仁山 陈晓红 冉新泽 程天民 |
| 作者单位： | 1. 第三军医大学大坪医院皮肤科,重庆,400042 2. 第三军医大学药理学教研室,重庆,400042 3. 第三军医大学预防医学院复合伤研究室,创伤、烧伤与复合伤国家重点实验室,重庆,400038 |
| 摘 要： | 作者介绍了高亲和力IgE受体介导I型超敏反应,其活化后的信号传导通路,及其相关的抑制性受体方面的研究进展,包括FcγRIIβ、PIR B、SIRPα、CD81及MAFA。对高亲和力IgE受体介导的信号通路和其相关的抑制性受体的研究将有可能发现对抗Ⅰ型超敏反应的新靶点,从而有助于过敏相关疾病的治疗。 |
| 关 键 词： | 高亲和力IgE受体 信号传导 抑制性受体 |
| 文章编号： | 1001-1978(2005)04-0385-05 |
| 修稿时间： | 2004-06-25 |
Signal transportation mediated by high-affinity IgE receptors and its inhibitory receprots related |
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| SUN Ren-shan,CHEN Xiao-hong,RAN Xin-ze,CHENG Tian-min. Signal transportation mediated by high-affinity IgE receptors and its inhibitory receprots related[J]. Chinese Pharmacological Bulletin, 2005, 21(4): 385-389 | |
| Authors: | SUN Ren-shan CHEN Xiao-hong RAN Xin-ze CHENG Tian-min |
| Abstract: | Type I Hypersensitivity reactions are mediated by high-affinity IgE receptors (FcεR1). The research progresses on FcεR1 signaling and its related inhibitory receptors were reviewed in this article. The inhibitory receptors include FcγRIIβ,PIR-B,SIRPα,CD81 and MAFA. Studies on FcεR1 signaling and its inhibitory receptors may show some new targets that can be used to antagonize type I hypersensitivity reactions, hereby benefiting to the reactions treatment. |
| Keywords: | high-affinity IgE receptors signal transduction inhibitory receptors |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |