被动吸烟和宫颈疾病的相关研究

目的:探讨被动吸烟与宫颈癌、宫颈上皮内瘤变(CIN Ⅰ~Ⅱ)发病的相关性。方法:回顾性研究被确诊并收治的原发性浸润性宫颈癌新发病例192例(宫颈癌组),CIN Ⅰ~Ⅱ 142例(CIN组),正常对照组254例(对照组),进行一对一的问卷调查,运用χ2检验和Logistic回归分析对被动吸烟与宫颈疾病发病的相关性进行分析。结果:无论是距诊断或就诊前近10年内还是10年以前,患病组和对照组是否被动吸烟、被动吸烟的持续时间、接触强度都有显著差别(P<0.01)。Logistic回归分析结果显示10年内被动吸烟时间是宫颈癌和CIN Ⅰ~Ⅱ发病危险因素,分娩次数和肿瘤家族史是CIN Ⅰ~Ⅱ的危险因素,高教育程度和年龄低是保护因素。结论:被动吸烟及接触时间、强度是宫颈疾病发病的相关危险因素。

Passive Cigarette Smoking in Cervical Disease Risk

Objective: To study the associations between passive smoking and cervical cancer,cervical intraepithelial neoplasia(CIN Ⅰ-Ⅱ) and its onset.Methods: A randomized,comparison survey was conducted on patients who visited the Obstetrics and Gynecology Hospital of Fudan University from June 2010 to October 2011.A total of 588 patients responded and were divided into 3 groups: the cervical squamous cell carcinoma group(cervical carcer group,192 cases),CIN Ⅰ-Ⅱ group(CIN group,142 cases),and control group(254 cases).The statistical methodologies of tests and conditional Logistic regressions were used to evaluate the correlation between passive smoking and cervical diseases.Results: No matter it’s within or before the last 10 years prior to diagnosis or treatment,and regardless of occurrences and durations of passive smoking,there were significant variances between cervical carcer group/CIN group and the control(P<0.01).The Logistic regression analysis showed that the duration of passive smoking in the last 10 years was a risk factor for cervical cancer and CIN Ⅰ-Ⅱ;times of baby delivery and family history of cancer were risk factors for CIN Ⅰ-Ⅱ;and level of education and age were protective factors in any circumstance.Conclusion: Passive smoking,exposure duration and the intensity of exposure are risk factors for cervical diseases.Whether at home or in public,smoking is harmful to both smokers and the surrounding non-smokers.