| 氢溴酸高乌甲素经皮渗透特性研究 |
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| 引用本文： | 邱永锋,赵苗,沙先谊,方晓玲. 氢溴酸高乌甲素经皮渗透特性研究[J]. 中国民族民间医药杂志, 2011, 0(20): 30-32 |
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| 作者姓名： | 邱永锋 赵苗 沙先谊 方晓玲 |
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| 作者单位： | [1]上海复旦大学药学院药剂学教研室,上海200032 [2]郑州大学药学院,河南郑州450052 |
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| 摘 要： | 目的：研究氢溴酸高乌甲素透皮吸收性能。方法：通过考察角质层和浓度两个因素。采用HPLC和TK-20B型透皮扩散试验仪测定氢溴酸高乌甲素透皮吸收性能。结果：去角质层后药物24h累积渗透量是完整皮肤的13．22倍，说明角质层是氢溴酸高乌甲素透皮的主要屏障；氢溴酸高乌甲素的透皮吸收速率与浓度并不成线性关系。结论：降低角质层屏障可改善氢溴酸高乌甲素透皮吸收，为其透皮吸收制剂的研究提供参考。
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| 关 键 词： | 氢溴酸高乌甲素 角质层屏障 透皮 |
Study on Lappaconitine Hydrobromide Transdermal |
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| Affiliation: | Qiu yong - feng , Zhao miao, Sha xian - yi , Fang xiao - ling( 1. Department of Pharmaceutics, Fudan University, Shanghai 200322, China; 2. School of Pharmacy, Zhengzhou University, Zhenghzou 450052, China) |
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| Abstract: | objection： To Study the transdermal for Lappaconitine Hydrobromide. Methods： Through Study two transdermal factor of horny layer and concentration for Lappaconitine Hydrobromide. Testing its transdermal absorption performance through HPLC and TK-20B skin diffusion test instruments. Results： the Q （Accumulation osmolality） of the gommage at 24th hour is 13. 22 times more than the Q of integrity skin; And the transdermal is not linear with the concentration of Lappaconitine Hydrobromide. Conclusions： Reduce the Horny layer barrier can improve the transdermal of Lappaconitine Hydrobromide. This paper can serve as reference for other similar study. |
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| Keywords: | Lappaconitine Hydrobromide Horny layer barrier Transdermal |
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