基于三重网络模型的酒精使用障碍患者静息态fMRI研究

目的:基于静息态功能磁共振(rs-fMRI)的独立成分分析(ICA)方法探讨酒精使用障碍(AUD)患者静息状态下三重网络模型(默认网络、突显网络及中央执行网络)功能网络连接(FNC)改变.方法:搜集2019年9月-2020年6月本院32例酒精使用障碍者和21例健康志愿者(正常对照组)的临床和MRI资料.所有被试行颅脑常...

Study of resting-state fMRI in patients with alcohol use disorder based on a triple-network model

Objective:To explore the functional network connectivity(FNC)changes of triple-network model(default mode network,salience network and central executive network)in patients with alcohol use disorder(AUD)by independent component analysis(ICA)based on resting-state functional magnetic resonance imaging(rs-fMRI).Methods:32 patients with alcohol use disorder(alcohol use disorder group)and 21 healthy volunteers(healthy control group)were collected from September 2019 to June 2020,all subjects underwent routine brain magnetic resonance imaging(MRI)and resting-state functional magnetic resonance imaging(rs-fMRI)scans,data were preprocessed by DPABI software,independent component analysis(ICA)was carried out by GIFT software,and independent component(IC)of default mode network(DMN)、salience network(SN)and central executive network(CEN)were identified.The general data of the two groups were compared by independent sample t-test,and the differences of FNC of the ICs in DMN,SN and CEN between the two groups were compared using two-sample t-test.Results:After routine scanning and head movement test,28 patients with alcohol use disorder and 19 healthy controls were included in the study.Compared with the healthy control group,the functional connections between IC8 and IC14,and IC10 and IC28 in CEN of AUD patients were significantly enhanced;the functional connections between IC1 of DMN and IC 28 of CEN,and IC6 of DMA and IC8 of CEN in AUD group were significantly enhanced;furthermore,the functional connections of IC8 in CEN with IC9 and IC18 in DMN,and IC22 in SN were significantly enhanced in the AUD group,and the differences between the two groups were all statistically significant(P<0.05).Conclusion:The functional connections within and between triple-network in patients with AUD are changed.