| 甲状旁腺全切除术治疗难治性继发性甲状旁腺功能亢进 |
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| 引用本文： | 花瞻,张凌,姚力,卞维静. 甲状旁腺全切除术治疗难治性继发性甲状旁腺功能亢进[J]. 中国耳鼻咽喉头颈外科, 2010, 17(8): 393-395 |
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| 作者姓名： | 花瞻 张凌 姚力 卞维静 |
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| 作者单位： | 北京卫生部中日友好医院普外科,北京,100029;北京卫生部中日友好医院肾病中心,北京,100029 |
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| 基金项目： | 首都医学发展科研基金资助项目(2009-3023) |
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| 摘 要： | 目的回顾性总结甲状旁腺全切除术治疗继发性甲状旁腺功能亢进的疗效。方法选择18例患者行甲状旁腺全切除术、终末期肾病（end stage renal disease,ESRD）且长期行血液透析,平均透析（114.06±50.38）个月,平均年龄（48.56±11.70）岁。收集患者术前、术后血液中全段甲状旁腺激素（intact parathyroid hormone,iPTH）,血清钙（Ca）、磷（P）和血清碱性磷酸酶（alkaline phosphatase,ALP）的结果,症状、术后并发症、死亡率和复发情况并判断其疗效。结果术后18例患者无一例死亡,2例患者发生一过性喉返神经损伤（11.1%）。低钙血症发生率高达72.2%（13/18）,血清钙术后1周内下降明显,6个月后渐回升至正常水平（P=0.000）,iPTH和血清磷明显降低（P=0.000）。患者的骨痛及皮肤瘙痒症状全部缓解,肌无力、失眠和纳差症状快速改善,全身营养状况好转。血清ALP在术后1周时有短暂升高,此后水平逐渐降低（P=0.449）。结论甲状旁腺全切除术治疗终末期肾病所致的难治性继发性甲状旁腺亢进是一种安全、有效的方法。
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| 关 键 词： | 甲状旁腺功能亢进症 继发性 甲状旁腺切除术 终末期肾病 |
Total parathyroidectomy for secondary hyperparathyroidism |
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| HUA Zhan,ZHANG Ling,YAO Li,BIAN Weijing. Total parathyroidectomy for secondary hyperparathyroidism[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2010, 17(8): 393-395 |
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| Authors: | HUA Zhan ZHANG Ling YAO Li BIAN Weijing |
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| Affiliation: | HUA Zhan1,ZHANG Ling2,YAO Li1,BIAN Weijing2 (1 Department of General Surgery,2 Department of Nephrology,China-Japan Friendship Hospital,Beijing,100029,China) |
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| Abstract: | OBJECTIVE To review the efficacyof total parathyroidectomy in patients with secondary hyperparathyroidism. METHODS Eighteen patients with end stage renal disease(ESRD)who underwent total parathyroidectomy were included in this study. Parameters measured included perioperative and postoperative(one week, one month and six months)biochemistry tests (intact parathyroid hormone, total calcium, inorganic phosphate and alkaline phosphatase), symptom relief, postoperative complications, mortality and presence of r... |
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| Keywords: | Hyperparathyroidism Secondary Parathyroidectomy end stage renal disease |
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