| 用正交试验法优选保肾灵胶囊的提取工艺 |
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| 引用本文： | 张娴,康阿龙,孙成荣,韦秋莉. 用正交试验法优选保肾灵胶囊的提取工艺[J]. 药学服务与研究, 2010, 10(5): 381-384 |
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| 作者姓名： | 张娴 康阿龙 孙成荣 韦秋莉 |
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| 作者单位： | 解放军451医院药剂科,西安,710054 |
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| 摘 要： | 目的：优选保肾灵胶囊的最佳提取工艺。方法：采用L9（34）正交试验设计,以浸膏得率,多糖、黄芪甲苷和二苯乙烯苷含量为评价指标筛选最佳提取工艺。分别用紫外分光光度法、薄层色谱法和HPLC法测定多糖、黄芪甲苷和二苯乙烯苷的含量。结果：最佳工艺为A2B2C3,即加10倍量水,提取3次,提取时间为1.5h。结论：该制备工艺合理、稳定和可行。
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| 关 键 词： | 保肾灵胶囊 提取工艺 正交试验 多糖类 黄芪甲苷 二苯乙烯苷 |
Optimization of the technology for extraction of Baoshenling capsules by orthogonal design |
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| ZHANG Xian,KANG Along,SUN Chengrong,WEI Qiuli. Optimization of the technology for extraction of Baoshenling capsules by orthogonal design[J]. Pharmaceutical Care and Research, 2010, 10(5): 381-384 |
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| Authors: | ZHANG Xian KANG Along SUN Chengrong WEI Qiuli |
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| Affiliation: | (Departmant of Pharmacy,No.451 Hospital of PLA,Xi’an 710054,China) |
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| Abstract: | Objective：To optimize the technology for extraction of Baoshenling capsules.Methods：Orthogonal design [L9（34）] was used to select the best extraction technology.The extract yield,contents of polysaccharide,astragaloside and stilbene glycoside were used as criteria of screen.Contents of polysaccharide,astragaloside and stilbene glycoside were determined by ultraviolet spectrophotometry,thin layer chromatography and HPLC methods,respectively.Results：The optimal technology was achieved by 1.5 h extraction with 10-fold volume of water for 3 times.Conclusion：The technology is reasonable,stable and feasible. |
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| Keywords: | Baoshenling capsules extraction technology orthogonal test polysaccharides astragaloside stilbene glycoside |
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