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| WR-2721及胎肝对放烧复合伤小鼠的防治作用 | |
| 引用本文： | 罗成基,施炎,郭朝华,伍军. WR-2721及胎肝对放烧复合伤小鼠的防治作用[J]. 第三军医大学学报, 1986, 0(4) |
| 作者姓名： | 罗成基 施炎 郭朝华 伍军 |
| 作者单位： | 第三军医大学卫防系防原医学教研室(罗成基，施炎，郭朝华)，第三军医大学卫防系防原医学教研室(伍军) |
| 摘 要： | 重度放射损伤复合重度烧伤小鼠伤前给WR-2721[S-2(3-氨丙基氨基)乙基硫代磷酸]预防,伤后输注1×10~6同种异基因胎肝细胞悬液治疗,能明显降低动物死亡率,延长死亡动物平均活存日。与对照动物相比,外周血白细胞计数、骨髓有核细胞总数、骨髓CFU-C(粒系造血干细胞)损伤轻、恢复快。外周血酯酶染色的T淋巴细胞计数改变不如骨髓CFU-C变化明显。输注胎肝治疗合并应用辐射防护剂WR-2721对重度放射损伤复合重度烧伤的效果,超过单用胎肝细胞输注或WR-2721的效果。 |
| 关 键 词： | WR-2721 胎肝输注 放烧复合伤防治 |
Protective Effect of WR-2721 and Fetal Liver Cell Transplantation on Combined Radiation-Burn Injury in Mice |
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| Luo Chengji,et al. Protective Effect of WR-2721 and Fetal Liver Cell Transplantation on Combined Radiation-Burn Injury in Mice[J]. Acta Academiae Medicinae Militaris Tertiae, 1986, 0(4) | |
| Authors: | Luo Chengji et al |
| Abstract: | Mice inflicted with severe combined radiation-burn injury were treated with WR-2721 and allogenic fetal liver cell transplantation. The mortality of the treated group was significantly lower and the mean survival time longer than the control. When compared w'th those of the control, the changes of the per pheral white count, the count of the nucletaed cells of the bone marrow, and the bone marrow CFU-C of the treated group were less marked and returned to normal more rap:dly. The changes of the peripheral T-lymphocyte count was not so marked as that of the bone marrow CFU-C.The combined therapeutic efficacy of WR-2721 and fetal cell transplantation was more prominant in treating the combined radiation and burn injury than either of the two agents used alone. |
| Keywords: | WR-2721 Fetal cell transplantation Combined radiation-burn injnry |
| 本文献已被 CNKI 等数据库收录！ | |