Pyretic action of low doses of gamma-hydroxybutyrate in rats |
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| Authors: | E E Kaufman L J Porrino T Nelson |
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| Affiliation: | Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, MD 20892. |
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| Abstract: | ![]()
gamma-Hydroxybutyrate (GHB) has been found to have a biphasic effect on body temperature with increased body temperature after low doses (5-10 mg/kg) and decreased body temperature after high doses (300-500 mg/kg). Brain levels of GHB between 30 and 60 min post-injection of GHB were not altered by the low doses (5-10 mg/kg), although a dose of 200 mg/kg produced a large increase in the brain concentration. |
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