The genotype nucleophosmin mutated and FLT3‐ITD negative is characterized by high bax/bcl‐2 ratio and favourable outcome in acute myeloid leukaemia |
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| Authors: | Giovanni Del Poeta Emanuele Ammatuna Serena Lavorgna Giovanni Capelli Serena Zaza Fabrizio Luciano Tiziana Ottone Maria Ilaria Del Principe Francesco Buccisano Luca Maurillo Paola Panetta Paolo De Fabritiis Roberto Stasi Adriano Venditti Sergio Amadori Francesco Lo Coco |
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| Affiliation: | 1. Department of Haematology, Ospedale S.Eugenio, University Tor Vergata, Rome;2. Fondazione Santa Lucia, Laboratorio di Neuro‐Oncoematologia, Rome;3. Department of Health and Sport Science, University of Cassino, Cassino, Italy;4. Department of Haematology, St. George’s Hospital, London, UK |
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| Abstract: | Nucleophosmin gene (NPM1) mutations characterize acute myeloid leukaemia (AML) with normal karyotype and frequently co‐exist with FLT3 internal tandem duplications (ITD). We evaluated bcl‐2, bax, NPM1 and FLT3‐ITD in 222 AML patients. Bax/bcl‐2 ratio >0·35 and NPM1 without FLT3‐ITD were significantly associated (P = 0·0001). NPM1‐mutated (mt)/FLT3‐ITD negative patients showed a higher complete remission (CR) rate (90%, P = 0·0002) and a longer overall survival (OS, P = 0·00007). NPM1‐mt/FLT3‐ITD negative plus bax/bcl‐2 > 0·35 subset showed a very high CR rate (96%), very long OS (P = 0·00005) and disease‐free survival (P = 0·004). The favourable prognosis of NPM1‐mt/FLT3‐ITD negative patients might be explained by a higher bax/bcl‐2 ratio. |
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| Keywords: | acute myeloid leukaemia bax/bcl‐2 FLT3‐ITD nucleophosmin gene prognosis |
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