microRNA对周围神经再生的调控作用

microRNA(miRNA)是高度保守的内源性非编码RNA,在多种生理和病理过程中起着重要的作用。周围神经损伤后,许多miRNA的表达发生显著变化。差异表达的miRNA负向调控其靶基因的表达,从而影响受损周围神经的再生和重塑。本综述从miRNA对神经元、施万细胞、失神经支配肌肉等的影响,阐明miRNA在周围神经过程中的调控作用。对于miRNA在周围神经损伤和再生过程中作用的研究,有助于更好地理解周围神经损伤后的内在分子调控机制,为将miRNA作为临床治疗的靶点提供了坚实的基础。

Regulatory effect of microRNAs on peripheral nerve regeneration

microRNAs (miRNAs) are a class of highly conserved endogenous non-coding RNAs. Emerging studies demonstrate that miRNAs play important roles in many physiological and pathological processes. Following peripheral nerve injury, the expression levels of numerous miRNAs change significantly. Differentially expressed miRNAs negatively regulate their target genes, and thus affect the regeneration and reconstruction of injured peripheral nerve. In the current review, the authors discuss the regulatory effect of miRNAs on neuron, Schwann cells, and denervated muscles. A full cognition of these differentially expressed miRNAs benefits the understanding of the intrinsic molecular mechanisms underlying peripheral nerve regeneration and may provide a new strategy for the clinical application of miRNAs.