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Effects of cardiopulmonary bypass on tight junction protein expressions in intestinal mucosa of rats |
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| Authors: | Sun Ying-Jie Chen Wei-Min Zhang Tie-Zheng Cao Hui-Juan Zhou Jin |
| Institution: | 1. Department of Anesthesiology, ShengJing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China;Department of Anesthesiology, the Northern Hospital of China, Shenyang 110016, Liaoning Province, China 2. Department of Anesthesiology, ShengJing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China 3. Department of Anesthesiology, the Northern Hospital of China, Shenyang 110016, Liaoning Province, China |
| Abstract: | AIM: To investigate the tight junction protein expressions of intestinal mucosa in an experimental model of cardiopulmonary bypass (CPB) in rats. METHODS: Thirty anesthetized rats were randomly divided into two groups: Group S (n = 10) served as sham operation and group C (n = 20) served as CPB which underwent CPB for 1 h. Expression of occludin and zonula occludens-1 (ZO-1) were determined by Western blotting and immunotochemistry, respectively. Plasma levels of diamine oxidase (DAO) and d-lactate were det... |
| Keywords: | Cardiopulmonary bypass Occludin ZO-1 Tight junction Diamine oxidase d-lactate |
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