Cardiovascular and Stroke Risk in Japanese Hemodialysis Patients With Atrial Fibrillation |
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| Authors: | Jumpei Hasegawa Brian Bieber Maria Larkina Bruce M. Robinson Sachiko Wakai Tadao Akizawa Akira Saito Shunichi Fukuhara Takashi Akiba |
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| Affiliation: | 1. Department of Nephrology, Ohkubo Hospital, Tokyo, Japan;2. Arbor Research Collaborative for Health, Ann Arbor, Michigan, USA;3. Division of Nephrology, Department of Medicine, Showa University School of Medicine, Japan;4. Shonantoubu General Hospital, Kanagawa, Japan;5. Department of Healthcare Epidemiology, Kyoto University Graduate School of Medicine and Public Health, Kyoto, Japan;6. Department of Blood Purification, Tokyo Women's Medical University, Japan |
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| Abstract: | Atrial fibrillation is one of the most common arrhythmias in hemodialysis patients. We evaluated its clinical outcomes among hemodialysis patients with atrial fibrillation in Japan. Using data derived from the Japanese Dialysis Outcomes and Practice Patterns Study, we analyzed backgrounds and outcomes among hemodialysis patients with and without atrial fibrillation in Japan. Among 7002 hemodialysis patients, the prevalence of atrial fibrillation was 5.7% and the incidence was 0.2 per 100 patient‐years. Atrial fibrillation was independently associated with all‐cause mortality (hazard ratio, 1.32; 95% confidence interval, 1.02–1.71) and cardiovascular events (hazard ratio, 1.39; 95% confidence interval, 1.15–1.68), but not with stroke events (hazard ratio, 0.77; 95% confidence interval, 0.55–1.06) after adjustment for other variables. We conclude that patients with atrial fibrillation experienced higher mortality and more cardiovascular events than did patients without atrial fibrillation, although the risk of stroke was lower than expected. |
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| Keywords: | Anticoagulation Atrial fibrillation Cardiovascular disease Hemodialysis Stroke |
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