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| c-Kit蛋白在小细胞肺癌中的表达及临床病理意义 | |
| 引用本文： | 韩春荣,李志强,董秀.c-Kit蛋白在小细胞肺癌中的表达及临床病理意义[J].牡丹江医学院学报,2006,27(4):4-6. |
| 作者姓名： | 韩春荣 李志强 董秀 |
| 作者单位： | 1. 牡丹江医学院附属红旗医院病理科,157011 2. 牡丹江医学院病理教研室 3. 牡丹江市公安局 |
| 摘 要： | 目的:探讨c-Kit蛋白的表达与小细胞肺癌(SCLC)发生、发展的关系.方法:应用免疫组化SABC法检测65例手术切除SCLC、癌旁组织和正常肺组织中,c-Kit蛋白的表达.结果:SCLC中c-Kit蛋白阳性表达率明显高于正常肺组织和癌旁组织(P《0.05).c-Kit蛋白的表达与肿瘤大小以及预后生存期密切相关(P《0.05).与SCLC患者性别、年龄、淋巴结转移情况无明显相关(P》0.05).结论:c-Kit蛋白的表达与SCLC的发生、发展及肿瘤大小及预后密切相关. |
| 关 键 词： | 抑癌基因c-Kit 免疫组织化学 预后 |
| 收稿时间： | 12 28 2005 12:00AM |
| 修稿时间： | 2005年12月28 |
EXPRESSION OF C - KIT IN SMALL CELL LUNG CANCER AND ITS CLINICO - PATHOLOGICAL SIGNIFICANCE |
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| Han Chunrong et al..EXPRESSION OF C - KIT IN SMALL CELL LUNG CANCER AND ITS CLINICO - PATHOLOGICAL SIGNIFICANCE[J].Journal of Mudanjiang Medical College,2006,27(4):4-6. | |
| Authors: | Han Chunrong |
| Institution: | Department of Pathology ,Affiliated Hospital of Mudanjiang Medical College 157011 |
| Abstract: | Objective:To investigate the relationship between the expression of c-Kit protein and its clinical pathology in small cell lung cancer(SCLC).Methods:Immunohistochemical technique was used to detect the expression of c-Kit protein in 65 cases of SCLC,adjacent tissues of cancer and normal tissues.Results:The rate of expression of c-Kit protein in tumor tissues was significantly higher than that in adjacent tissues of cancer and normal tissues(P<0.05).It was show that the expression of c-Kit protein closely correlate to the size of the tumor and the prognosis of patients with SCLC.There was no obvious correlation between the expression of c-Kit protein and the sex,age and the lymph node metastasis of the patients with SCLC(P>0.05).Conclusion:There are close correlations between the expression of the c-Kit protein and the development of SCLC and the prognosis of patients. |
| Keywords: | SCLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |