The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes |
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Authors: | Wei Michael Ong Leslie Smith Maree T Ross Fraser B Schmid Katrina Hoey Andrew J Burstow Darryl Brown Lindsay |
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Affiliation: | Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, Brisbane, Australia. |
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Abstract: | BACKGROUND: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes is streptozotocin (STZ)-induced diabetes in the rat. METHODS: This project assessed cardiovascular, ocular and neuropathic changes over a period of 24 weeks post STZ administration in rats. RESULTS: STZ-diabetic rats (n = 96) showed stable signs of diabetes (hyperglycaemia, increased water and food intake with no increase in bodyweight): 52% of untreated STZ-diabetic rats (n = 50) survived 24 weeks after STZ administration. STZ-diabetic rats were normotensive with slowly developing systolic and diastolic dysfunction and an increased ventricular stiffness. Ventricular action potential durations were markedly prolonged. STZ-diabetic rats developed stable tactile allodynia. Cataracts developed to presumed blindness at 16 weeks but proliferative retinopathy was not observed even after 24 weeks. CONCLUSION: The chronic STZ-diabetic rat mimics many but not all of the chronic complications observed in the diabetic human. The chronic STZ-diabetic rat may be a useful model to test therapeutic approaches for amelioration of chronic diabetic complications in humans. |
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Keywords: | Author Keywords: cataracts diabetes echocardiography electrophysiology neuropathic pain retinopathy |
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