显微镜下多血管炎16例临床病理分析

目的:探讨显微镜下多血管炎(M PA)的临床和病理特征,为早期诊断提供依据。方法:对16例临床确诊的M PA病人的临床、病理改变进行回顾性分析。结果:M PA在临床表现,实验室检查,辅助检查及病理活检等方面各有特点。病理活检有诊断价值,P-ANCA/抗M PO抗体阳性对诊断M PA有特异性。结论:M PA是一种可累及多个器官的全身性疾病,临床表现复杂多样且无特异性,对可疑病人及时行病理活检和(或)ANCA测定可帮助早期诊断。

Clinical and pathological analysis of 16 cases of microscopic polyangitis

Objective: To investigate the clinical and pathological features of microscopic polyangitis(MPA) and to improve the level of it's early diagnosis.Methods: The clinical and pathological changes of 16 patients with MPA were retrospectively analyzed and summarized.Results: MPA has its own characteristics in symptoms,laboratory and pathology manifestations.Pathologic biopsy is valuable and positive result of either P-ANCA or MPO-antibody is specific for the diagnosis of MPA.Conclusion: Because MPA is a systemic disease which involves many organs of an individual and cause various non-specific clinical manifestations,timely detection of ANCA and /or pathologic biopsy are recommended for early diagnosis.