儿童过敏性紫癜诊治进展

过敏性紫癜是儿童时期常见的系统性血管炎,新的诊断标准将皮肤紫癜作为必要条件。因此,以腹痛为首发症状者早期较难诊断,而胃镜检查和凝血因子ⅩⅢ活性测定可提高本病早期诊断率,胰岛素样生长因子、胰岛素样生长因子结合蛋白3及肾尿表皮生长因子可以预测过敏性紫癜肾损害,为临床干预提供依据。过敏性紫癜治疗以药物为主,糖皮质激素和免疫抑制剂是治疗本病的有效药物并改善预后,麦考酚酯治疗本病前景广阔。

Update on the diagnosis and treatment of Henoch-Sehonlein purpura in children

Henoch-Schonlein purpura is a common systemic vasculitis in childhood. Palpable purpura is the mandatory criterion for the diagnosis of this disease in the new criteria. Early diagnosis is difficult in children who presented initially with abdominal pain. Gastroscopy and detection of the activity of coagulation factor XIII may facilitate its early diagnosis. The serum level of insulin-like growth factor, insulin-like growth factor binding protein 3 and urine epidermal growth factor can predict renal damage in allergic purpura, so as to provide a basis for clinical intervention. Henoch-Schonlein purpura is primarily dealed with medication. In particular, glucocorticoid and immunosuppressants can effectively control the disease and improve its prognosis. Mycophenolate has exhibited a good prospect in the treatment of this disease.