国产冻干水痘减毒活疫苗的安全性及免疫原性观察 |
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引用本文: | 陈思富,;蒋征刚,;李倩,;唐学雯,;董晓莲,;葛君华,;林云,;龚晓英,;方杭燕,;赵东设.国产冻干水痘减毒活疫苗的安全性及免疫原性观察[J].中国计划免疫,2009(5):435-437. |
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作者姓名: | 陈思富 ;蒋征刚 ;李倩 ;唐学雯 ;董晓莲 ;葛君华 ;林云 ;龚晓英 ;方杭燕 ;赵东设 |
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作者单位: | [1]浙江省疾病预防控制中心,杭州310051; [2]德清县疾病预防控制中心,浙江德清313200; [3]天台县疾病预防控制中心,浙江天台317200; [4]嘉兴市疾病预防控制中心,浙江嘉兴314050; [5]衢州市疾病预防控制中心,浙江衢州324000; [6]杭州市余杭区疾病预防控制中心,浙江杭州311100; [7]温州市鹿城区疾病预防控制中心,浙江温州325000 |
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摘 要: | 目的观察国产冻干水痘减毒活疫苗(Varicella Attenuated Live Vaccine,Freeze-dried;VarV)的安全性及免疫原性。方法对未感染水痘-带状疱疹病毒、1~13岁健康儿童,接种国产VarV进行安全性观察,应用膜免疫荧光抗体方法检测水痘抗体。结果观察对象接种后30min和4h、24h、48h、72h的不良反应发生率,分别为2.29%、3.69%、3.82%、1.78%、0.25%,6周后无不良反应报告。总发热反应率为3.82%,注射部位红肿反应发生率为3.69%,局部硬结发生率为0.64%。VarV免疫后,免疫成功率为98.3%,免疫前、后抗体几何平均滴度增长明显。结论国产VarV临床反应轻微,安全性和免疫原性良好。
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关 键 词: | 国产冻干水痘减毒活疫苗 安全性 免疫原性 |
Safety and Immunogenicity of Lyophilized Live Attenuated Domestic Varicella Vaccine |
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Institution: | CHEN En- fu, JIANG Zheng-gang, LI Qian, et al. (Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China.) |
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Abstract: | Objective To evaluate the safety and immunogenicity of the lyophilized live attenuated domestic varicella vaccine of Oka strain in Zhejiang province. Methods 785 susceptible children aged 1-13 years, who had no history of VZV infection and had not been immunized, were observed. Results The results showed that 2.29% children had adverse reactions after 30mins of inoculation, 3.69% children had adverse reactions after 4 hours, 3.82% children had adverse reactions after 24 hours, 1.78% children had adverse reactions after 48 hours, 0.25% children had adverse reactions after 72 hours, no adverse reactions were observed after six weeks. There were 3.82% children had fever, The incidence rate of other adverse reactions such as swel 1 and scleroma were low. The vaccine had high sero-converson rate. Condusion The results showed that it has good safety and immunogenicity of the live attenuated domestic varicella vaccine. |
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Keywords: | Lyophilized live attenuated varicella vaccine Safety Immunogenicity |
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