精神分裂症首次发病患者的磁共振弥散张量显像研究

目的探讨从未用过药的精神分裂症首次发病(以下简称首发)患者的重要白质及部分灰质区的磁共振弥散张量显像(DTI)的特点。方法选取9例首发精神分裂症患者(患者组)及9名年龄、性别、受教育程度与患者组相配对的健康者,应用DTI成像技术检测脑额颞交界处、内囊等白质区和颞中回灰质、中央前回、中央后回等灰质区的各向异性(FA)、表观扩散系数(ADC)及双侧海马体积。结果患者组及对照组组内左右两侧兴趣区FA值及ADC值的差异无统计学意义(P>0.05);患者组与对照组各感兴趣区FA值差异无统计学意义(P>0.05),但患者组颞中回灰质(8.655×10-9)、中央前回(7.816×10-9)、中央后回(7.855×10-9)ADC值高于对照组(分别为7.428×10-9,6.921×10-9,7.013×10-9;P=0.049,0.009,0.005);两组内及组间双侧海马体积比较,差异均无统计学意义(P>0.05)。结论首发精神分裂症患者与健康者DTI参数之间没有明显区别。

The white matter and grey matter in the first episodic schizophrenia: a diffusion tensor imaging study

Objective This study was to measure white matter and grey matter in some brain regions of neuroleptics-free patients with first episodic schizophrenia using the diffusion tensor magnetic resonance imaging(DTI).Methods DTI was performen in a sample of 9 first episode schizophrenic patients and 9 gender-,age-,and education-matched controls.Regions of interest were placed in the relay of temporal and frontal lobe,internal capsule,hippocampus,precentral gyrus,and postcentral gyrus,and fractional anisotropy(FA) and apparent diffusion coefficient(ADC) were measured.Z-test was used to test group differences,with group as between-subjects factor and side as within-subjects factor.Results (1) No differences of FA and ADC in ROIs between left and right sides were found in both patients and controls((P>0.05).)(2) There were no differences of FA in the ROIs between patients and controls(P>0.05),while the ADR in the middle temporal lobe,precentral gyrus and postcentral gyrus were significantly higher in patients than in controls(P<0.05).(3) There were no differences in the hippocampus volume between both the groups(P>0.05).Conclusions No difference of DTI parameters are found between the first episode schizophrenic patients and healthy controls in this study.