The immunomodulatory effects of titanium dioxide and silver nanoparticles |
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| Affiliation: | 1. Laboratory of Molecular Biology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland;2. Division of Nutrition Physiology, Department of Dietetics, Faculty of Human Nutrition and Consumer Science, Warsaw University of Life Sciences – SGGW, Nowoursynowska 151C, 02-776 Warsaw, Poland;3. Centre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland;4. Department of Radiobiology and Immunology, Institute of Biology, Jan Kochanowski University, Świetokrzyska 15, 25-406 Kielce, Poland;5. Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences – SGGW, Nowoursynowska 159, Warsaw 02-776, Poland;6. Department of Molecular Biology and Translational Research, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland;7. Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Sucharskiego 2, Rzeszów, Poland;1. Departamento de Fisiología (Biología Celular), Instituto Nacional de Cardiología “Ignacio Chávez”, Mexico;2. Departamento de Posgrado, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico;3. Departamento de Microscopía Electrónica, Instituto Nacional de Cancerología, Mexico;4. Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología, Mexico;5. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico;6. Departamento de Inmunología, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico;8. Swedish Toxicology Sciences Research Center (Swetox), Södertälje, Sweden;9. Academia de Biología, Colegio de Ciencias y Humanidades, Universidad Autónoma de la Ciudad de México, Mexico;1. Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, CP 54059, Estado de México, Mexico;2. Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, Mexico;3. Programa de Maestría en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico;4. Doctorado en Ciencias en Alimentos, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, CP 11340, México DF, Mexico;5. Centro de Ciencias Aplicadas y Desarrollo Tecnológico, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria AP 70-186, CP 04510, México DF, Mexico;6. Department of Infectomics and Molecular Pathogenesis, Center for Research and Advanced Studies, CINVESTAV-IPN, Avenida Instituto Politécnico Nacional 2508, San Pedro Zacatenco, 07360, Mexico, DF, Mexico;7. Laboratorio 209, Edificio F, Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, CP 04510, México DF, Mexico;8. Experimental Pathology Section, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Vasco de Quiroga 15, Colonia Sección XVI, Tlalpan, México DF, 14000, Mexico;9. Carrera De Médico Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, CP 54059, Estado de México, Mexico;10. Department of Toxicogenomics, Maastricht University, PO Box 616, 6200MD, Maastricht, The Netherlands;1. Guizhou Provincial People’s Hospital, Guiyang 550002, China;2. Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;1. Department of Molecular Biology and Translational Research, Institute of Rural Health, Lublin, Poland;2. Institute of Nuclear Chemistry and Technology, Centre for Radiobiology and Biological Dosimetry, Warsaw, Poland;3. Department of Medical Biology and Translational Research, Faculty of Medicine, University of Information Technology and Management, Rzeszów, Poland |
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| Abstract: | Due to their characteristic physical, chemical and optical properties, titanium dioxide and silver nanoparticles are attractive tools for use in a wide range of applications. The use of nanoparticles for biological applications is, however, dependent upon their biocompatibility with living cells. Because of the importance of inflammation as a modulator of human health, the safe and efficacious in vivo use of titanium dioxide and silver nanoparticles is inherently linked to a favorable interaction with immune system cells. However, both titanium dioxide and silver nanoparticles have demonstrated potential to exert immunomodulatory and immunotoxic effects. Titanium dioxide and silver nanoparticles are readily internalized by immune system cells, may accumulate in peripheral lymphoid organs, and can influence multiple manifestations of immune cell activity. Although the factors influencing the biocompatibility of titanium dioxide and silver nanoparticles with immune system cells have not been fully elucidated, nanoparticle core composition, size, concentration and the duration of cell exposure seem to be important. Because titanium dioxide and silver nanoparticles are widely utilized in pharmaceutical, commercial and industrial products, it is vital that their effects on human health and immune system function be more thoroughly evaluated. |
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| Keywords: | Nanomaterials Immunomodulation Immunotoxicity Titanium dioxide nanoparticles Silver nanoparticles |
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