|
|||||
|
|
| 胃癌中肿瘤微环境转移的价值 | |
| 引用本文： | 齐蕾,单丽辉,柴翠翠,周秋锋,姚珂,顾云鹤,周敏,韩伟,王立峰. 胃癌中肿瘤微环境转移的价值[J]. 临床与实验病理学杂志, 2012, 28(3): 274-277 |
| 作者姓名： | 齐蕾 单丽辉 柴翠翠 周秋锋 姚珂 顾云鹤 周敏 韩伟 王立峰 |
| 作者单位： | 齐蕾 (哈尔滨医科大学附属第一临床医院病理科,哈尔滨,150001) ； 单丽辉 (哈尔滨医科大学附属第一临床医院病理科,哈尔滨,150001) ； 柴翠翠 (哈尔滨医科大学附属第一临床医院病理科,哈尔滨,150001) ； 周秋锋 (哈尔滨医科大学附属第一临床医院病理科,哈尔滨,150001) ； 姚珂 (哈尔滨医科大学附属第一临床医院病理科,哈尔滨,150001) ； 顾云鹤 (哈尔滨医科大学附属第一临床医院病理科,哈尔滨,150001) ； 周敏 (哈尔滨医科大学附属第一临床医院病理科,哈尔滨,150001) ； 韩伟 (哈尔滨医科大学附属第一临床医院病理科,哈尔滨,150001) ； 王立峰 (哈尔滨医科大学附属第一临床医院病理科,哈尔滨,150001) ； |
| 基金项目： | 黑龙江省自然科学基金,黑龙江省教育厅科学技术研究项目 |
| 摘 要： | 目的研究胃癌中是否存在肿瘤微环境转移(tumor microenvironment of metastasis,TMEM)及其与胃癌血道转移的相关性。方法采用免疫组化双染法同时标记巨噬细胞和内皮细胞,计数26例远处转移及其配对26例无远处转移胃癌组织中TMEM密度。结果 (1)TMEM存在于胃癌组织中;(2)TMEM与分化程度、临床分期明显相关(P<0.001,P=0.006),与肿瘤大小、Lauren分型、淋巴结转移等其他临床病理特点无关(P均>0.05);(3)TMEM与有无远处转移呈正相关(P<0.001)。结论证实胃癌中存在TMEM,TMEM密度可以预测胃癌血道转移,有望成为评估胃癌血道转移危险性的新预测指标。 |
| 关 键 词： | 胃肿瘤 肿瘤相关巨噬细胞 微血管密度 肿瘤微环境转移 血道转移 |
The value of tumor microenvironment of metastasis in gastric cancer |
|
| QI Lei,SHAN Li-hui,CHAI Cui-cui,ZHOU Qiu-feng,YAO Ke,GU Yun-he,ZHOU Min,HAN Wei,WANG Li-feng. The value of tumor microenvironment of metastasis in gastric cancer[J]. Chinese Journal of Clinical and Experimental Pathology, 2012, 28(3): 274-277 | |
| Authors: | QI Lei SHAN Li-hui CHAI Cui-cui ZHOU Qiu-feng YAO Ke GU Yun-he ZHOU Min HAN Wei WANG Li-feng |
| Affiliation: | (Department of Pathology,the First Affliated Hospital of Harbin Medical University,Harbin 150001,China.) |
| Abstract: | Purpose To investigate whether or not present tumor microenvironment of metastasis(TMEM) in gastric cancer and its relationship with hematogenous metastases.Methods A case-control study of 26 patients who developed metastatic gastric cancer and 26 patients without metastatic disease was done.Paraffin-embedded gastric cancer samples were stained using double-immunostaining method allowing simultaneous identification of macrophages and endothelial cells.Then TMEM density was evaluated.Results(1)TMEM was present in gastric cancer.(2)TMEM density was related to cancer differentiation and clinical stages(P<0.001,P=0.006),but had no relationship with other characteristics of pathology,such as the tumor size,Lauren classification and lymph node metastasis(P>0.05).(3)TMEM density had a positive correlation with distant metastasis(P<0.001).Conclusions They demonstrate that TMEM is present in gastric cancer.TMEM density can predict the development of hematogenous metastases and may be a useful new prognostic marker for gastric cancer patients. |
| Keywords: | gastric neoplasms tumor associated macrophages microvessel density tumor microenvironment of metastasis hematogenous metastases |
| 本文献已被 CNKI 等数据库收录！ | |