大鼠尾-壳核痛反应神经元对伤害性重复刺激的反应

本文通过重复刺激坐骨神经的方法,进一步探讨了痛兴奋神经元的电活动。结果发现,大鼠尾-壳核内存在着一种特殊类型的痛反应神经元,即痛抑制-兴奋神经元。

Responses of the Neurons in Caudate-putamen Nucleus to Repeated Noxious Stimuli in the Rat

By the method of repeated noxious stimuli to sciatic nerve we studied the electrical activities of pain excitation neurons, i.e.during the discharges evoked by the former noxious stimulation (S_1) the latter noxious stimulation (S_2) was given in order to observe the responses to S_2. A Special type of responses to S_2 was found in the caudate-putamen nucleus: S_2 stopped the discharges evoked by S_1. The duration interrupted by S_2 was markedly shorter than the latency of the discharges evoked by S_1 (P<0.01). They showed significant (P<0.05) linear correlation (r=0.510). The results suggest that some of pain excitation neurons with very low spontaneous firing and very long latency be possibly a special type of pain reaction neurons. After noxious stimulation these neurons showed inhibition at first, and then excitation.