| 抗CCP抗体联合RF检测类风湿性关节炎诊断试验Meta分析 |
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| 引用本文： | 杨奕,刁建萍,刘重阳.抗CCP抗体联合RF检测类风湿性关节炎诊断试验Meta分析[J].职业与健康,2012,28(3):270-273. |
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| 作者姓名： | 杨奕 刁建萍 刘重阳 |
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| 作者单位： | 第三军医大学大坪医院野战外科研究所风湿免疫科,重庆市,400042 |
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| 摘 要： | 目的通过诊断试验Meta分析,综合评价抗环瓜氨酸肽抗体(CCP)和类风湿因子(RF)联合诊断类风湿关节炎(RA)的效果。方法通过检索万方、维普、CNKI等数据库,获得有关抗CCP和RF联合诊断RA的文献,提取相关数据;采用SAS 8.02进行诊断试验Meta分析。结果抗CCP/RF并联的准确度为0.803,诊断优势比为16.590;抗CCP+RF串联的准确度为0.841,诊断优势比为27.781;两种联合诊断准确度比较,差异无统计学意义(P0.05)。结论抗CCP和RF联合诊断效果较好,并联能够提高灵敏度,串联能够提高特异度,联合诊断对RA具有较高的诊断价值。
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| 关 键 词： | 类风湿性关节炎 抗环瓜氨酸肽抗体 类风湿因子 Meta分析 |
Meta-analysis of diagnostic tests for rheumatoid arthritis with the screening methods of Anti-CCP and RF |
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| YANG Yi
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DIAO Jian-ping
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LIU Chong-yang.Meta-analysis of diagnostic tests for rheumatoid arthritis with the screening methods of Anti-CCP and RF[J].Occupation and Health,2012,28(3):270-273. |
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| Authors: | YANG Yi DIAO Jian-ping LIU Chong-yang |
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| Institution: | Department of Rheumatology,Daping Hospital,Chongqing,400042,China |
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| Abstract: | Objective]To comprehensively evaluate the effect of anti-cyclic citrullinated peptide antibody(Anti-CCP) and rheumatoid factor(RF) on diagnosis of rheumatoid arthritis(RA) through Meta-analysis of diagnostic tests.Methods]By search literature database such as Wangfang,Weipu,CNKI,the related literatures were obtained for data extraction.SAS 8.02 was adopted for Meta-analysis.Results]Meta analysis indicated that the accuracy of anti-CCP/RF was 0.803 and diagnostic OR was 16.590.Those of anti-CCP+RF screening method were 0.841 and 27.781 respectively.The difference of accuracy between 2 methods was not significant(P>0.05).Conclusion]Both anti-CCP/RF and anti-CCP+RF can be used in diagnosis of RA with good effect.Anti-CCP/RF can raise sensitivity,and Anti-CCP+RF can heighten specificity.So this combination diagnosis has good value for RA diagnosis. |
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| Keywords: | Rheumatoid arthritis(RA) Anti-cyclic citrullinated peptide antibody(Anti-CCP) Rheumatoid factor Meta-analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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