| Studies on Toxicity of Nitroquine-Dapsone Compound and Therapeutic Effects of Folic or Folinic Acid on Toxicated Animals |
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| 作者姓名： | 胡友梅 程天民 李先珍 况明书 朱青平 刘富安 吴廷璜 |
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| 作者单位： | Department of Pharmacology Third Military Medical College，Chongqing，Department of Pharmacology，Third Military Medical College，Chongqing，Department of Pharmacology，Third Military Medical College，Chongqing，Department of Pharmacology，Third Military Medical College，Chongqing，Department of Pharmacology，Third Military Medical College，Chongqing，Department of Pharmacology，Third Military Medical College，Chongqing，Department of Pharmacology，Third Military Medical College，Chongqing，Department of medical protection Department of parasitology |
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| 摘 要： | The toxic effects of nitroquine-dapsone compound(NQD)in mice and dogs were studied.The therapeutic index of NQDin mice is 1911,the greatest among the 6 antimalarials tested.Thetoxic effects of NQD(50 mg/kg/day for 3 days per os)and nitro-quine in dogs were manifested by injuries on the adrenal cortexand intestinal epithelium.When folic acid(4 mg/kg/day for 4 days)or calcium leucovorinum(0.3 mg/kg/day for 4 days)were usedconcomitantly with NQD,the death rate and the incidence of dia-rrhea in the toxicated dogs were greatly reduced,the injury on theintestinal epithelium was much milder,and the goblet cells weremuch more numerous than those without treatment.The results suggestthat folic acid and calcium leucovorinum can protect the undifferen-tiated cells in the intestinal crypts from being injured by NQD.
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Studies on Toxicity of Nitroquine-Dapsone Compound and Therapeutic Effects of Folic or Folinic Acid on Toxicated Animals |
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| Hu Youmei Cheng Tianmin Li Xianzhen Kuang Mingshu Zhu Qingping Liu Fu'an Wu Tinghuang.Studies on Toxicity of Nitroquine-Dapsone Compound and Therapeutic Effects of Folic or Folinic Acid on Toxicated Animals[J].Journal of Medical Colleges of PLA(China),1986(3). |
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| Authors: | Hu Youmei Cheng Tianmin Li Xianzhen Kuang Mingshu Zhu Qingping Liu Fu'an Wu Tinghuang |
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| Institution: | Hu Youmei Cheng Tianmin Li Xianzhen Kuang Mingshu Zhu Qingping Liu Fu'an Wu Tinghuang Department of Pharmacology,Third Military Medical College,Chongqing. Department of medical protection
Department of parasitology |
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| Abstract: | The toxic effects of nitroquine-dapsone compound(NQD) in mice and dogs were studied.The therapeutic index of NQD in mice is 1911,the greatest among the 6 antimalarials tested.The toxic effects of NQD(50 mg/kg/day for 3 days per os)and nitro- quine in dogs were manifested by injuries on the adrenal cortex and intestinal epithelium.When folic acid(4 mg/kg/day for 4 days) or calcium leucovorinum(0.3 mg/kg/day for 4 days)were used concomitantly with NQD,the death rate and the incidence of dia- rrhea in the toxicated dogs were greatly reduced,the injury on the intestinal epithelium was much milder,and the goblet cells were much more numerous than those without treatment.The results suggest that folic acid and calcium leucovorinum can protect the undifferen- tiated cells in the intestinal crypts from being injured by NQD. |
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| Keywords: | antimalarial drugs nitroquine(NQ) nitroquinedapsone(NQD) folic acid calcium leucovorinum(folinic acid) |
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