卡泊三醇搽剂联合氟芬那酸丁酯软膏治疗头部慢性湿疹与神经性皮炎的疗效观察

目的:观察卡泊三醇搽剂联合氟芬那酸丁酯软膏治疗头部慢性湿疹与神经性皮炎的疗效。方法:71例头部慢性湿疹与神经性皮炎患者采用随机数字表法随机分成两组。治疗组35例,每天早晨、中午各1次将氟芬那酸丁酯软膏涂于患处;晚上外用卡泊三醇搽剂喷于皮损处后涂抹数次,每天1次。对照组36例,每天早晨、中午各1次将氟芬那酸丁酯软膏涂于患处;晚上外用哈西奈德溶液涂搽患处皮损后涂抹数次,每天1次。连用4周,治疗结束后评价疗效并记录不良反应。结果:治疗组与对照组的有效率分别为91.4%、88.9%(P>0.05);两组治疗前及治疗4周后湿疹面积及严重度指数(EASI)评分比较差异均无统计学意义(P>0.05)。结论:卡泊三醇搽剂联合氟芬那酸丁酯软膏治疗头部慢性湿疹与神经性皮炎疗效肯定、副作用少。

Efficacy Observation of Calcipotriol Linimentum Combined with Butyl Flufenamate Ointment in the Treatment of Cephalic Chronic Eczema and Neurodermatitis

OBJECTIVE： To observe therapeutic efficacy of Calcipotriol linimenturn combined with Butyl flufenamate ointment for cephalic chronic eczema and neurodermatitis. METHODS： 71 cases of cephalic chronic eczema and neurodermatitis were randomly divided into 2 groups. 35 cases in treatment group were treated with Butyl flufenamate ointment twice a day, morning and noon, and Calcipotriol linimentum once a day at night. 36 cases in control group were treated with Butyl flufenamate ointment twice a day, morning and noon, and Halcinonide solution once a day at night. After 4 weeks, therapeutic efficacy was evaluated and ADR was recorded at the end of treatment. RESULTS： The effective rate of treatment group was 91.4% and that of control group was 88.9% （P〉0.05） ; there was no statistical significance in the difference of eczema area and EASI between 2 groups before treatment and 4 weeks after treatment （P〉0.05）. CONCLUSIONS： Calcipotriol linimentum combined with Butyl flufenamate ointment are effective for cephalic chronic eczema and neurodermatitis with less side effect.