利培酮致不良反应142例分析

目的:探讨利培酮致不良反应(ADR)的特点及规律,为临床合理用药及安全性评价提供参考。方法:采用病例回顾性研究方法,对某院2010-2012年收集到的142例利培酮致ADR报告相关信息进行统计、分析。结果:142例报告中,以21～40岁年龄段患者发生ADR最为普遍(70例,占49.30%);多发生于用药2周内;有128例(占90.14%)使用2种及以上抗精神病药物联合治疗;ADR以神经系统损害最为常见,达94例次(占48.45%),主要表现为锥体外系反应,其次为心血管系统损害(40例次,占20.62%);经停药、减量或对症处理后ADR均好转或痊愈。结论:利培酮的ADR可累及多个器官/系统,临床表现多样,且与多种因素有关,临床应重视并加强其ADR的监测,尽可能减少联合用药,以避免或减少其ADR的发生。

Analysis of 142 Cases of Adverse Drug Reaction Induced by Risperidone

OBJECTIVE： To investigate the characteristics and general pattern of adverse drug reaction （ADR） induced by risperidone, and to provide reference for rational drug use and safety evaluation. METHODS： A total of 142 ADR cases induced by risperidone collected from our hospital during 2010-2012 were analyzed statistically retrospectively. RESULTS： Among 142 cases of ADR reports, the majority were young people aged 21-40 years old （70 cases, 49.30% ） ; most of cases developed within 2 weeks. 128 patients （90.14%） were treated with more than 2 kinds of antipsychotic agents. ADR mostly were nervous system disorders （94 cases, 48.45% ）, manifesting as extrapyramidal disease, followed by cardiovascular system injury （40 cases, 20.62% ）; ADR were improved or cured after drug withdrawal, reduction or treatment. CONCLUSIONS： Risperidone-induced ADR involve various organs or system, has multiple clinical manifestations which is related to various factors. ADR monitoring should be strengthened in the clinic. Drug combination should be reduced as far as possible to avoid or reduce the occurrence of ADR.