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| 人乳头瘤病毒分型联合液基细胞学检测在宫颈病变筛查中的意义 | |
| 引用本文： | 朱园园,程志祥,李兵,赵婷婷,伍娇. 人乳头瘤病毒分型联合液基细胞学检测在宫颈病变筛查中的意义[J]. 中国临床保健杂志, 2014, 0(3): 243-245 |
| 作者姓名： | 朱园园 程志祥 李兵 赵婷婷 伍娇 |
| 作者单位： | [1]安徽医科大学附属省立医院、安徽省立医院分子实验室,合肥230001 [2]安徽省合肥市第二人民医院检验科,合肥230001 |
| 基金项目： | 中华医学会分子生物学临床应用研究专项资金（CAMB022010） |
| 摘 要： | 目的探讨人乳头瘤病毒(HPV)分型联合细胞学检测在子宫颈病变筛查中的意义。方法收集疑似宫颈病变患者408例,分别进行细胞学和HPV基因芯片分型检测,了解各亚型HPV感染率及其与细胞学结果的相关性,判断HPV感染与年龄的关系,进行统计学分析。结果在高危型感染中居于前3位的分别是HPV 16、58、52。单一高危型HPV感染率随宫颈病变级别升高呈增加趋势,且差异有统计学意义(r=0.879,P0.05)。高危型HPV感染率在年龄分布上呈两端高的趋势(25岁和50岁),但各年龄组间差异无统计学意义。结论 HPV分型检测宜联合细胞学应用于宫颈病变的筛查及临床治疗和随访。 |
| 关 键 词： | 宫颈疾病 α乳头状瘤病毒属 细胞学技术 |
The combination of Liquid based cytology and human papilloma virus testing for screening cervical lesions |
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| ZttU Yuanyuan,CHENG Zhixiang,LI Bing,ZHAO Tinging,WU Jiao. The combination of Liquid based cytology and human papilloma virus testing for screening cervical lesions[J]. Chinese Journal of Clinical Healthcare, 2014, 0(3): 243-245 | |
| Authors: | ZttU Yuanyuan CHENG Zhixiang LI Bing ZHAO Tinging WU Jiao |
| Affiliation: | ( Laboratory of Molecular Medicine,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001, China) |
| Abstract: | Objective To evaluate the Liquid based cytology and human papilloma virus test for screening cervical lesions.Methods 408 suspected patients with cervical lesion from our gynecological outpatient service were collected.The liquid-based cytology and human papilloma virus（HPV）test were used,and the correlation of subtypes of HPV infection with cytology and age were observed.Results The top three HR-HPV genotypes were 16,58,52. The high-risk HPV infection rate increased with lesion grade（r=0.879,P〈0.05）.Conclusions The combination of HPV with liquid-based cytology testing should be applied in the screening,treatment and follow-up of cervical lesions. |
| Keywords: | Uterine cervical diseases Alphapapillomavirus Cytological techniques |
| 本文献已被 CNKI 维普 等数据库收录！ | |