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Nimodipine treatment of subarachnoid hemorrhage |
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| Authors: | J Laursen F Jensen E Mikkelsen P Jakobsen |
| Institution: | a Department of Neurosurgery, University Hospital of Århus, Nørrebrogade 44, DK 8000, Århus C, Denmark b Institute of Pharmacology, Bartholin Building, University of Århus N, DK 8000, Århus C, Denmark |
| Abstract: | In a pilot study of 6 patients with subarachnoid hemorrhage caused by a ruptured intracranial (grade IV (Hunt and Hess) aneurysm the hemodynamics and plasma-nimodipine concentrations have been observed during a 3-week period of treatment. We found that 3 patients developed reversible hypotension during the nimodipine treatment and that the hypotension tendency could be related to the plasmanimodipine level and not to a more or less severe sensitivity to nimodipine. Repeated measurements of blood pressure, plasma-nimodipine and regional cerebral blood flow (rCBF) are necessary for the purpose of obtaining the optimum treatment and for evaluating the effect of treatment. |
| Keywords: | subarachnoid hemorrhage nimodipine reversible hypotension |
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