妊娠期糖尿病孕妇血清视黄醇结合蛋白4、内脂素水平的变化及其临床意义

目的探讨妊娠期糖尿病(GDM)患者血清视黄醇结合蛋白4(RBP4)、内脂素水平变化的意义,研究视黄醇结合蛋白4和内脂素与胰岛素抵抗(IR)的相关性。方法采用稳态模型评估法评估正常糖耐量孕妇(NGT)、糖耐量减低孕妇(GIGT)和妊娠期糖尿病孕妇(GDM)的胰岛素抵抗指数,采用酶联免疫吸附法检测所有受试者的空腹血糖(FPG)、空腹胰岛素(FINS)、RBP4和内脂素水平。结果 GDM组和GIGT组血清RBP4、内脂素和胰岛素抵抗指数(HO-MA-IR)均显著高于NGT组(P<0.01)。血清RBP4、内脂素与HOMA-IR均呈显著正相关。结论妊娠期糖尿病患者存在胰岛素抵抗,RBP4、内脂素可影响妊娠期糖尿病患者IR的程度。

Study of correlation of serum retinol binding protein 4 and visfatin in gestational diabetes mellitus with insulin resistance.

Objective： It is to investigate the changes of serum RBP4 and visfatin levels in GDM and the relationship of RBP4, visfatin with insulin resistance. Methods： Homeostasis model assessment （HOMA） was adopted to evaluate insulin resistance in NGT, GIGT and GDM groups. The levels of fasting plasma glucose, insulin, RBP4 and visfatin were measured by enzyme - linked immu- nosorbent assay （ELISA） among three groups. Results ： The levels of RBP4, visfatin and HOMA - IR were significantly higher in GDM and GIGT groups than those in the NGT group （P 〈0. 01 ）. The RBP4 and visfatin were postively correlated with HOMA - IR. Conclusion ： Insulin resistance exists in patients with GDM. The RBP4 and visfatin may affect the extend of IR in patients with GDM.