胎盘中SDF-1/CXCR4的表达与妊娠期高血压疾病的关系

目的研究趋化因子SDF-1及其受体CXCR4在妊娠期高血压疾病患者胎盘中的表达,分析其表达水平变化与妊娠期高血压疾病发病之间的关系。方法采用免疫组织化学法检测妊娠期高血压疾病患者胎盘组织中SDF-1、CXCR4的表达强度及表达范围。结果随着妊娠期高血压疾病病情程度的加重,胎盘组织中SDF-1及CXCR4表达强度及范围均呈渐进性下降趋势,且SDF-1的表达强度及范围明显优于CXCR4的表达强度及范围。结论 SDF-1、CXCR4表达强度及范围的变化与妊娠期高血压疾病的发病有重要关系。

The relationship between expression of SDF-1/CXCR4 in placenta and development of hypertensive disorder complicating pregnancy

Objective： To investigate the expression of SDF-1 and its receptor CXCR4 in placenta of patients of hypertensive disorder complicating pregnancy,analyze the relationship between their expression and the development of hypertensive disorder complicating pregnancy.Methods： The expression intension and extent of SDF-1,CXCR4 in placenta of patients of hypertensive disorder complicating pregnancy were measured by Immunohistochemical method.Results： Along with the deterioration and development of hypertensive disorder complicating pregnancy,the expression intension and extent of SDF-1 and CXCR4 in placenta were gradually decreasing.The expression intension and extent of SDF-1 were superior to the expression intension and extent of CXCR4.Conclusions： The variety of the expression intension and extent of SDF-1,CXCR4 has an important relationship with the development of hypertensive disorder complicating pregnancy.