The effects of SKF 525-A on hepatic glycogen and rate of hepatic drug metabolism |
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| Affiliation: | 1. Departments of Obstetrics and Gynecology, Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do, 10380, Republic of Korea;2. Departments of Family Medicine, Center for Health Promotion, Inje University Ilsan Paik Hospital, Goyang-si, Gyeonggi-do, 10380, Republic of Korea;3. Department of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT, 59812, USA;4. Department of Health, Environment and Safety, School of Human & Environmental Service, Eulji University, Seongnam-si, Gyeonggi-do, 13135, Republic of Korea;1. Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, China;2. Key Laboratory of Agri-food Quality and Safety, Ministry of Agriculture and Rural Affairs, Beijing 100081, China |
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| Abstract: | The level of hepatic glycogen and rates of certain drug metabolisms were studied after administration of SKF 525-A (β-diethylaminoethyl diphenylpropyl acetate HCl) to adult rats. SKF 525-A inhibits hepatic drug metabolism within 1 hr, and a significant effect is seen up to 24 hr after administration. SKF 525-A lowers hepatic glycogen to a minimum level in 8 to 12 hr. The recovery of hepatic glycogen and rate of hepatic drug metabolism to control values occurs at the same time after administration of SKF 525-A. The effects of SKF 525-A on certain enzymes of hepatic glycogenesis and glycogenolysis were also studied. |
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