| 家蚕核型多角体病毒DNA的病毒学评价 |
| |
| 引用本文： | 王苏华,何家禄,端礼荣,季平,李卫党,肖庆利,陆荣柱.家蚕核型多角体病毒DNA的病毒学评价[J].中国公共卫生学报,1999(6). |
| |
| 作者姓名： | 王苏华 何家禄 端礼荣 季平 李卫党 肖庆利 陆荣柱 |
| |
| 作者单位： | 江苏镇江医学院医学检验系!镇江212001(王苏华，端礼荣，李卫党，肖庆利，陆荣柱)，中国农业科学院镇江蚕业研究所(何家禄，季平) |
| |
| 摘 要： | 毒理学评价结果揭示，家蚕核型多角体病毒为无毒级；微核试验阴性，致畸试验也未获得阳性结果，同时慢性毒性试验结果表明，受试物可减缓受试动物的体重增长，并具有不同程度的肾和肝脏毒性。
|
| 关 键 词： | 家蚕核型多角体病毒 微核 毒性 安全性评价 |
Toxicological Evaluation of DNA of Nuclear Polyherdrosis Virus of silkworm |
| |
| Authors: | Wang Suhua |
| |
| Institution: | Zhenjing 212001 |
| |
| Abstract: | Toxicological eveluation of DNA of muclear polyherdrosis virus(NPV) of silkworm was conducted to provide toxicological evidence to protect the health of workers engaged in genetic engineering and its biosafety.The results showed that NPV DNA belongs to no toxicity class in acute toxicity test,and bone marrow cell micronucleus rate of mice administrated by NPV DNA was not significantly higher than that of control group.The positive results of traditional teratogenic study in rate were not obtained,and chronic toxicological study showed that NPV DNA retarded the growth rate of treated rats in the begining,but later the growth rate was recovered gradually,and that some beginning,but latetr the growth rate waw recovered gradually,and that some positive pathological changes in lungs,livers and kidneys were found in group with higher dosage of NPV DNA. |
| |
| Keywords: | NPV Micronucleus rate Toxicity Safety Evaluation |
| 本文献已被 CNKI 等数据库收录！ |
|
