Chromosomal anomaly of 6q in chronic myelogenous leukemia (CML) |
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| Authors: | Ashok K. Srivastava Ralph A. Gruppo Carl W. Siegrist |
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| Affiliation: | 1. Department of Pathology, University of Cincinnati Medical Center, Cincinnati, Ohio USA.;2. Department of Pediatrics, Division of Hematology-Oncology, Children''s Hospital Medical Center, Cincinnati, Ohio USA.;3. Department of Pediatrics, Division of Hematology-Oncology, Children''s Hospital Medical Center, Siegrist and Kollman, Inc., Cincinnati, Ohio USA. |
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| Abstract: | Anomalies of chromosome 6q, along with other chromosomal anomalies, are described in the bone marrow cells of two patients with chronic myelogenous leukemia (CML). One patient, a 14-year-old male, developed the karyotype 46,XY,t(1;6)(p36;q15),del(3)(q25),del(17)(p11),? inv(17)(q12q24) during blastic crisis of his disease. The other patient, a 24-year-old male, had the karyotype 46,XY,del(6)(q13),t(9;22)(q34;q11) during the early phase of his disease and evolution of i(17q) in the karyotype late in the disease. |
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| Keywords: | Address requests for reprints to: Ashok K. Srivastava Department of Pathology University of Cincinnati Medical Center 231 Bethesda Avenue Cincinnati OH 45267. |
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