血必净注射液在腹部外科围手术期的疗效观察

目的 探讨血必净注射液对腹部外科术后炎性反应、感染并发症、住院时间以及肝肾功能的影响.方法 采用前瞻性随机对照研究,将60例腹部手术的患者按随机数字表法分为对照组(术后常规治疗)和治疗组(术后在常规治疗基础上加用血必净注射液),每组30例.分别于术前1d、术后3 d、术后7 d监测两组患者炎性反应指标(体温、心率、白细胞计数)、肝肾功能指标(转氨酶、总胆红素、肌酐、血尿素氮),并比较两组患者感染并发症及住院时间.结果 治疗组术后3 d的体温、白细胞计数显著低于对照组体温:(37.0±0.2)℃比(37.9±0.4)℃;白细胞计数:(8.8±1.1)×109/L比(10.3±1.7)×109/L,P＜0.05],住院时间显著低于对照组(8.7±1.9)d比(10.9±1.6)d,P＜0.05],两组患者的肝肾功能指标比较差异无统计学意义(P＞0.05),感染并发症发生率比较差异无统计学意义3.3%(1/30)比6.7%(2/30),P＞0.05].结论 血必净注射液能显著减轻腹部手术后炎性反应,缩短住院时间,短期观察无明显肝肾不良反应.

Study of the efficacy of xuebijing injection applied after abdominal operation

Objective To investigate the effect of xuebijing injection applied after abdominal operation on the inflammatory reaction,infection rate,length of stay and hepatorenal function. Methods Sixty patients received abdominal operations were randomly divided into therapeutic group (30 cases) and control group (30 cases). The inflammatory reaction indexes (temperature,heart rate,leucocyte) and hepatorenal function indexes(aminopherase, total bilirubin, creatinine, blood urea nitrogen) were observed in both groups before operation and after operation 3,7 days respectively. The infection rate and length of stay were compared in two groups. Results Temperature and leucocyte post operative 3 days temperature:(37.0 ± 0.2) ℃ vs. (37.9 ± 0.4) ℃ ;leucocyte: (8.8 ± 1.1 ) × 109/L vs. ( 10.3 ± 1.7) × 109/L, P＜ 0.05] and length of stay in therapeutic group was obviously better than that in control group (8.7 ± 1.9 ) d vs. ( 10.9±1.6) d, P ＜ 0.05 ]. The hepatorenal function indexes and infection rate in both groups had no significant difference(P ＞ 0.05). Conclusion Xuebijing injection could significantly palliate the inflammatory reaction after abdominal operation, shorten the length of stay and has no hepatorenal toxicity in short term.