| 外源性玻璃酸钠对骨关节炎患者血液及滑液基质金属蛋白酶-3的影响 |
| |
| 引用本文： | 张向阳,孙正明,郭东武,甘沛,杨鲁源.外源性玻璃酸钠对骨关节炎患者血液及滑液基质金属蛋白酶-3的影响[J].西部医学,2009,21(9):1538-1539. |
| |
| 作者姓名： | 张向阳 孙正明 郭东武 甘沛 杨鲁源 |
| |
| 作者单位： | 1. 兰州大学附属天浩医院骨科,甘肃,兰州,730060
2. 西安交通大学第一医院骨科,陕西,西安,710061 |
| |
| 摘 要： | 目的探讨外源性玻璃酸钠（SodiumHyaluronate，SH）对骨关节炎（osteoarthritis0A）患者的血清及滑液中基质金属蛋白酶-3（matrixmetalloproteinase-3，MMP-3）的影响。方法30例膝关节OA患者，关节内注射玻璃酸钠1次／周，连用5次，治疗前后均空腹抽取血液及滑液，检测MMP-3的水平。结果治疗后血清和滑液中的MMP-3含量均降低，与治疗前相比有显著性差异（P〈0．05）。结论外源性玻璃酸钠可以直接或间接调节MMP-3水平，从而治疗膝OA。
|
| 关 键 词： | 玻璃酸钠 骨关节炎 基质金属蛋白酶-3 |
The effect of extraneous sodium hyaluronate on the level of MMP-3 in serum and synovial fluid of patients with osteoarthritis |
| |
| Institution: | ZHANG Xiang-yang, SUN Zheng-ming, GUO Dong-wu, et al (Department of Osteology , Tianhao Hospital, Nanzhou University, Nanzhou 730060) |
| |
| Abstract: | Objective To investigate the effect of extraneous sodium hyaluronate（SH） on the level of MMP-3 in serum and synovial fluid of patients with osteoarthritis（OA）. Methods 30 patients with knee OA were injected with SH （2ml） once a week for 5 continuous week. Both before and after treatment fasting blood and synovial fluid samples to detect the level of MMP-3. Result The levels of MMP-3 after treatment in serum and synovial fluid significantly lower than those before treatment. Conclusion SH may be beneficial in the treatment of OA by adjusting the level of MMP-3. |
| |
| Keywords: | Sodium Hyaluronate Osteoarthritis Matrix metalloproteinase-3 |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
