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Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders |
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| Authors: | Carola Schaefer Frank Enning Juliane K. Mueller J. Malte Bumb Cathrin Rohleder Thorsten M. Odorfer Joachim Klosterkötter Martin Hellmich Dagmar Koethe Christian Schmahl Martin Bohus F. Markus Leweke |
| Affiliation: | 1. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, J5, 68159, Mannheim, Germany 2. Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany 3. Institute for Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany 4. Department of General Psychiatry, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany 5. Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany |
| Abstract: | Borderline personality (BPD) and complex posttraumatic stress disorders (PTSD) are both powerfully associated with the experience of interpersonal violence during childhood and adolescence. The disorders frequently co-occur and often result in pervasive problems in, e.g., emotion regulation and altered pain perception, where the endocannabinoid system is deeply involved. We hypothesize an endocannabinoid role in both disorders. We investigated serum levels of the endocannabinoids anandamide and 2-arachidonoylglycerol and related fatty acid ethanolamides (FAEs) in BPD, PTSD, and controls. Significant alterations were found for both endocannabinoids in BPD and for the FAE oleoylethanolamide in PTSD suggesting a respective link to both disorders. |
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